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. 1976 Jul;73(7):2515–2519. doi: 10.1073/pnas.73.7.2515

Morphine-like peptides in mammalian brain: isolation, structure elucidation, and interactions with the opiate receptor.

R Simantov, S H Snyder
PMCID: PMC430630  PMID: 1065904

Abstract

A substance that competes for opiate receptor binding has been isolated from calf brain and identified as two pentapeptides, H-Tyr-Gly-Gly-Phe-Met-OH (methionine enkephalin) and H-Tyr-Gly-Gly-Phe-Leu-OH (leucine enkephalin), with about four times more leucine enkephalin than methionine enkephalin. Sodium and manganese effects on opiate receptor interactions show that both peptides are agonists, whereas leucine enkephalin may be a "purer" agonist than methionine enkephalin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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