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. 1976 Aug;73(8):2872–2876. doi: 10.1073/pnas.73.8.2872

Experimental myasthenia in Balb/c mice immunized with rat acetylcholine receptor from rat denervated muscle.

D A Granato, B W Fulpius, J F Moody
PMCID: PMC430782  PMID: 1066700

Abstract

A new model of an autoimmune disease of the neuromuscular junction was obtained by injection of acetylcholine receptor purified from rat denervated muscles into Balb/c mice. Anti-rat, then anti-mouse acetylcholine receptor antibodies, appear in mouse serum during the immunization procedure. Electrophysiological investigations performed on immunized mice reveal a neuromuscular block similar to that found in myasthenia gravis. Not a single mouse with objective signs of muscular weakness was lacking anti-mouse acetylcholine receptor antibodies but no correlation was found between their level and the severity of the disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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