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. 1976 Aug;73(8):2890–2894. doi: 10.1073/pnas.73.8.2890

Aplastic anemia: presence in human bone marrow of cells that suppress myelopoiesis.

W A Kagan, J A Ascensão, R N Pahwa, J A Hansen, G Goldstein, E B Valera, G S Incefy, M A Moore, R A Good
PMCID: PMC430791  PMID: 1085449

Abstract

Bone marrow from a patient with aplastic anemia was shown by multiple criteria to have a block in early myeloid differentiation. This block was overcome in vitro by elimination of marrow lymphocytes. Furthermore, this differentiation block was transferred in vitro to normal marrow by coculturing with the patient's marrow. We suggest that some cases of aplastic anemia may be due to an immunologically based suppression of marrow cell differentiation rather than to a defect in stem cells or their necessary inductive environment.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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