Abstract
Chronic irradiation of mice with ultraviolet (UV) light produces a systemic alteration of an immunologic nature. This alteration is detectable in mice long before primary skin cancers induced by UV light begin to appear. The alteration results in the failure of UV-irradiated mice to reject highly antigenic, transplanted UV-induced tumors that are rejected by unirradiated syngeneic recipients. The immunologic aspect of this systemic alteration was demonstrated by transferring lymphoid cells from UV-irradiated mice to lethally x-irradiated recipients. These recipeints were unable to resist a later challenge with a syngeneic UV-induced tumor, whereas those given lymphoid cells from normal donors were resistant to tumor growth. Parabiosis of normal mice with UV-irradiated mice, followed by tumor challenge of both parabionts with a UV-induced tumor, resulted in the growth of the challenge tumors in both UV-irradiated and unirradiated mice. Splenic lymphocytes from tumor-implanted UV-treated mice were not cytotoxic in vitro against UV-induced tumors, whereas under identical conditions cells from tumor-implanted, unirradiated mice were highly cytotoxic. Our findings suggest that repeated UV irradiation can circumvent an immunologic mechanism that might otherwise destroy nascent UV-induced primary tumors that are strongly antigenic.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- EICHWALD E. J., LUSTGRAAF E. C., STRAINER M. Genetic factors in parabiosis. J Natl Cancer Inst. 1959 Dec;23:1193–1213. [PubMed] [Google Scholar]
- Horowitz S., Cripps D., Hong R. Selective T cell killing of human lymphocytes by ultraviolet radiation. Cell Immunol. 1974 Oct;14(1):80–86. doi: 10.1016/0008-8749(74)90171-3. [DOI] [PubMed] [Google Scholar]
- Kripke M. L. Antigenicity of murine skin tumors induced by ultraviolet light. J Natl Cancer Inst. 1974 Nov;53(5):1333–1336. doi: 10.1093/jnci/53.5.1333. [DOI] [PubMed] [Google Scholar]
- Kripke M. L., Fisher M. S. Immunologic parameters of ultraviolet carcinogenesis. J Natl Cancer Inst. 1976 Jul;57(1):211–215. doi: 10.1093/jnci/57.1.211. [DOI] [PubMed] [Google Scholar]
- Kripke M. L. Target organ for a systemic effect of ultraviolet radiation. Photochem Photobiol. 1976 Dec;24(6):599–600. doi: 10.1111/j.1751-1097.1976.tb06879.x. [DOI] [PubMed] [Google Scholar]
- Lucas Z. J., Walker S. M. Cytotoxic activity of lymphocytes. 3. Standardization of measurement of cell-mediated lysis. J Immunol. 1974 Jul;113(1):209–224. [PubMed] [Google Scholar]
- MARTINEZ C., SMITH J. M., SHAPIRO F., GOOD R. A. Transfer of acquired immunological tolerance of skin homografts in mice joined in parabiosis. Proc Soc Exp Biol Med. 1959 Nov;102:413–417. doi: 10.3181/00379727-102-25268. [DOI] [PubMed] [Google Scholar]
- Marshall V. Premalignant and malignant skin tumours in immunosuppressed patients. Transplantation. 1974 Mar;17(3):272–275. doi: 10.1097/00007890-197403000-00006. [DOI] [PubMed] [Google Scholar]
- Rao V. S., Bonavida B. Specific enhancement of tumor growth and depression of cell-mediated immunity following sensitization to soluble tumor antigens. Cancer Res. 1976 Apr;36(4):1384–1391. [PubMed] [Google Scholar]