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. 1977 Apr;74(4):1721–1723. doi: 10.1073/pnas.74.4.1721

5'-deoxypyridoxal as a potential anti-sickling agent.

R Benesch, R E Benesch, R Edalji, T Suzuki
PMCID: PMC430865  PMID: 266212

Abstract

5'-Deoxypyridoxal, which reacts specifically with the terminal amino groups of the alpha chains of hemoglobin, increases the oxygen affinity of hemoglobin solutions as well as of dilute suspensions of normal and sickle red cells and whole blood. As a result, the proportion of deoxyhemoglobin (which is responsible for sickling) is decreased at venous oxygen tensions and this is reflected by a sharply reduced sickle cell count in this range of oxygen pressures.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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