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. 1976 Sep;73(9):3165–3167. doi: 10.1073/pnas.73.9.3165

Tolerance and dependence evoked by an endogenous opiate peptide.

A Lampert, M Nirenberg, W A Klee
PMCID: PMC430968  PMID: 1067610

Abstract

Incubation of neuroblastoma X glioma hybrid cells for 12-97 hr with methionine-enkephalin results in an increase in adenylate cyclase activity [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] that is mediated by the opiate receptor. The results show that cells become tolerant to, and dependent upon, enkephalin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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