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. 1976 Sep;73(9):3253–3257. doi: 10.1073/pnas.73.9.3253

Neurophysiological defects in temperature-sensitive paralytic mutants of Drosophila melanogaster.

O Siddiqi, S Benzer
PMCID: PMC430996  PMID: 184469

Abstract

A new temperature-sensitive paralytic mutant of Drosophila, comatose, is compared behaviorally and physiologically with the previously known types, para and shi. All three have different properties with respect to kinetics of paralysis at high temperature and recovery from paralysis; com is hypersensitive to paralysis by cooling. Neurophysiological experimeents indicate different mechanisms for paralysis in each of the mutants.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Benzer S. BEHAVIORAL MUTANTS OF Drosophila ISOLATED BY COUNTERCURRENT DISTRIBUTION. Proc Natl Acad Sci U S A. 1967 Sep;58(3):1112–1119. doi: 10.1073/pnas.58.3.1112. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Grigliatti T. A., Hall L., Rosenbluth R., Suzuki D. T. Temperature-sensitive mutations in Drosophila melanogaster. XIV. A selection of immobile adults. Mol Gen Genet. 1973 Jan 24;120(2):107–114. doi: 10.1007/BF00267238. [DOI] [PubMed] [Google Scholar]
  3. HODGKIN A. L., KATZ B. The effect of temperature on the electrical activity of the giant axon of the squid. J Physiol. 1949 Aug;109(1-2):240–249. doi: 10.1113/jphysiol.1949.sp004388. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Ikeda K., Kaplan W. D. Patterned neural activity of a mutant Drosophila melanogaster. Proc Natl Acad Sci U S A. 1970 Jul;66(3):765–772. doi: 10.1073/pnas.66.3.765. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Ikeda K., Ozawa S., Hagiwara S. Synaptic transmission reversibly conditioned by single-gene mutation in Drosophila melanogaster. Nature. 1976 Feb 12;259(5543):489–491. doi: 10.1038/259489a0. [DOI] [PubMed] [Google Scholar]
  6. Katz B., Miledi R. The effect of temperature on the synaptic delay at the neuromuscular junction. J Physiol. 1965 Dec;181(3):656–670. doi: 10.1113/jphysiol.1965.sp007790. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kelly L. E., Suzuki D. T. The effects of increased temperature on electroretinograms of temperature-sensitive paralysis mutants of Drosophila melanogaster. Proc Natl Acad Sci U S A. 1974 Dec;71(12):4906–4909. doi: 10.1073/pnas.71.12.4906. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. MCCANN F. V., BOETTIGER E. G. Studies on the flight mechanism of insects. I. The electrophysiology of fibrillar flight muscle. J Gen Physiol. 1961 Sep;45:125–142. doi: 10.1085/jgp.45.1.125. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Suzuki D. T., Grigliatti T., Williamson R. Temperature-sensitive mutations in Drosophila melanogaster. VII. A mutation (para-ts) causing reversible adult paralysis. Proc Natl Acad Sci U S A. 1971 May;68(5):890–893. doi: 10.1073/pnas.68.5.890. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Williamson R., Kaplan W. D., Dagan D. A fly's leap from paralysis. Nature. 1974 Nov 15;252(5480):224–226. doi: 10.1038/252224a0. [DOI] [PubMed] [Google Scholar]

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