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. 2014 Dec 22;54(3):666–676. doi: 10.1021/bi501016r

Figure 4.

Figure 4

Resveratrol is not an effective inhibitor of amyloid formation by H18Q-IAPP. (A) Thioflavin-T-monitored kinetic experiments with H18Q-IAPP (black) and H18Q-IAPP and resveratrol at a 1:1 (yellow), 1:2 (green), 1:5 (pink), 1:10 (red), or 1:20 ratio (blue). (B) TEM image of the amyloid fibrils formed by H18Q-IAPP. (C) TEM image of the 1:10 mixture of H18Q-IAPP and resveratrol. (D) TEM image of the 1:20 mixture of H18Q-IAPP and resveratrol. Samples were collected for TEM at 48 h and contained 16 μM IAPP in pH 7.4, 20 mM Tris buffer with 1% (v/v) DMSO. Scale bars represent 100 nm.