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. 1976 Oct;73(10):3391–3393. doi: 10.1073/pnas.73.10.3391

A possible explanation for the nuclease limit digestion pattern of chromatin.

C R Cantor
PMCID: PMC431120  PMID: 1068452

Abstract

The general pattern of DNA fragments in the limit digest of nuclease-treated chromatin could arise from a single, unique nuclease-susceptible site per nucleosome. If DNA binds to the histone core of the nucleosome along a circularly re-entrant path, the location of the DNA entrance and exit can occur at any of a number of distinct sites. This very specific type of heterogeneity together with the natural 10-fold periodicity of DNA B can account for the observed digestion pattern. Such a general picture of the nucleosome structure could also easily explain how nucleosomes might move along the DNA. This type of structure should be easy to distinguish experimentally form more conventional explanations of the origin of the limit digest pattern of chromatin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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