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. 1976 Nov;73(11):3872–3876. doi: 10.1073/pnas.73.11.3872

DNA gyrase: an enzyme that introduces superhelical turns into DNA.

M Gellert, K Mizuuchi, M H O'Dea, H A Nash
PMCID: PMC431247  PMID: 186775

Abstract

Relaxed closed-circular DNA is converted to negatively supercoiled DNA by DNA gyrase. This enzyme has been purified from Escherichia coli cells. The reaction requires ATP and Mg++ and is stimulated by spermidine. The enzyme acts equally well on relaxed closed-circular colicin E1, phage lambda, and simian virus 40 DNA. The final superhelix density of the DNA can be considerably greater than that found in intracellularly supercoiled DNA.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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