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. 1977 Jul;74(7):2855–2859. doi: 10.1073/pnas.74.7.2855

Extensive disulfide bonding at the mammalian cell surface.

R O Hynes, A Destree
PMCID: PMC431319  PMID: 268636

Abstract

Cell surface proteins of cultured cells are disulfide bonded to a greater degree than are total cellular proteins. In particular, the "large external transformation-sensitive" (LETS) protein, a major surface protein, is present almost exclusively in disulfide-bonded complexes including homodimers and also higher aggregates held together by disulfide bonds or concovalent interactions. Other cell surface proteins also appear to be involved in disulfide bonding, both intramolecular and intermolecular. In virally transformed cells, LETS protein and its disulfide complexes are absent and certain other disulfide-bonded proteins are also not observed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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