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. 1976 Nov;73(11):4065–4069. doi: 10.1073/pnas.73.11.4065

Changes in microfilament organization and surface topogrophy upon transformation of chick embryo fibroblasts with Rous sarcoma virus.

E Wang, A R Goldberg
PMCID: PMC431329  PMID: 186784

Abstract

A series of morphological changes occurred when chick embryo fibroblasts infected with the NY68 mutant of Rous sarcoma virus were shifted from nonpermissive temperature (41degrees) to permissive temperature (37 degrees). We observed three distinct stages in cell morphology and surface topography that were correlated with a reduction in the organization and assembly of actin-containing microfilament bundles. Our observations suggest that control of microfilament organization and surface topography are responsive to the presence of a functioning transforming gene (src) product of Rous sarcoma virus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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