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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1976 Nov;73(11):4187–4189. doi: 10.1073/pnas.73.11.4187

beta-Endorphin: cross tolerance to and cross physical dependence on morphine.

L F Tseng, H H Loh, C H Li
PMCID: PMC431379  PMID: 186788

Abstract

The effects of beta-endorphin on the antinociceptive responses and abrupt withdrawal jumping in morphine-dependent mice were studied. Mice were rendered morphine dependent by implantation of a morphine pellet (75 mg base) for 3 days. The analgesic response to beta-endorphin decreased after morphine pellet implantation, as evidenced by an eight-fold increase in the median antinociceptive dose of morphine was found. In small doses (0.09-0.17 mug per mouse), beta-endorphin suppressed abrupt withdrawal jumping. Met-enkephalin, even in high doses (200 mug per mouse), did not suppress abrupt withdrawal jumping.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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