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. 1976 Nov;73(11):4195–4199. doi: 10.1073/pnas.73.11.4195

Dichloromethane as an antisickling agent in sickle cell hemoglobin.

B P Schoenborn
PMCID: PMC431382  PMID: 1069309

Abstract

Microscopic studies of red cells from homozygous sickle cell patients show that dichloromethane does prevent sickle cell formation in vitro and does cause reversion of sickled cells to normal after exposure to dichloromethane. X-ray structural analysis of human deoxyhemoglobin crystals exposed to dichloromethane shows four unique binding sites. Arguments are presented to suggest that the binding site close to tryptophan 14alpha prevents the formation of helical polymers, i.e., prevent sickling.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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