Abstract
Two components--one resembling intact cholecystokinin in size and charge and immunologic specificity, and the other resembling the COOH-terminal octapeptide of cholecystokinin--have been found in extracts of the pig cerebral cortex. The relative concentrations of the two peptides in the extracts were dependent on the extractant, boiling 0.1 M HCl being more effective than boiling water for the extraction of intact cholecystokinin but less effective for the extraction of the octapeptide. The physiologic role of these peptides in the brain has yet to be elucidated.
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Selected References
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- Bryant M. G., Polak M. M., Modlin I., Bloom S. R., Albuquerque R. H., Pearse A. G. Possible dual role for vasoactive intestinal peptide as gastrointestinal hormone and neurotransmitter substance. Lancet. 1976 May 8;1(7967):991–993. doi: 10.1016/s0140-6736(76)91863-8. [DOI] [PubMed] [Google Scholar]
- Dockray G. J. Immunochemical evidence of cholecystokinin-like peptides in brain. Nature. 1976 Dec 9;264(5586):568–570. doi: 10.1038/264568a0. [DOI] [PubMed] [Google Scholar]
- GOODFRIEND T. L., LEVINE L., FASMAN G. D. ANTIBODIES TO BRADYKININ AND ANGIOTENSIN: A USE OF CARBODIIMIDES IN IMMUNOLOGY. Science. 1964 Jun 12;144(3624):1344–1346. doi: 10.1126/science.144.3624.1344. [DOI] [PubMed] [Google Scholar]
- Gibbs J., Young R. C., Smith G. P. Cholecystokinin decreases food intake in rats. J Comp Physiol Psychol. 1973 Sep;84(3):488–495. doi: 10.1037/h0034870. [DOI] [PubMed] [Google Scholar]
- Gibbs J., Young R. C., Smith G. P. Cholecystokinin elicits satiety in rats with open gastric fistulas. Nature. 1973 Oct 12;245(5424):323–325. doi: 10.1038/245323a0. [DOI] [PubMed] [Google Scholar]
- Gregory R. A., Tracy H. J. Big gastrin. Mt Sinai J Med. 1973 May-Jun;40(3):359–364. [PubMed] [Google Scholar]
- Snyder S. H. Opiate receptors in the brain. N Engl J Med. 1977 Feb 3;296(5):266–271. doi: 10.1056/NEJM197702032960511. [DOI] [PubMed] [Google Scholar]
- Straus E., Muller J. E., Choi H. S., Paronetto F., Yalow R. S. Immunohistochemical localization in rabbit brain of a peptide resembling the COOH-terminal octapeptide of cholecystokinin. Proc Natl Acad Sci U S A. 1977 Jul;74(7):3033–3034. doi: 10.1073/pnas.74.7.3033. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Vanderhaeghen J. J., Signeau J. C., Gepts W. New peptide in the vertebrate CNS reacting with antigastrin antibodies. Nature. 1975 Oct 16;257(5527):604–605. doi: 10.1038/257604a0. [DOI] [PubMed] [Google Scholar]
- Yalow R. S., Berson S. A. Further studies on the nature of immunoreactive gastrin in human plasma. Gastroenterology. 1971 Feb;60(2):203–214. [PubMed] [Google Scholar]