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. 1977 Aug;74(8):3330–3334. doi: 10.1073/pnas.74.8.3330

Selective inhibition of gamma-glutamyl-cycle enzymes by substrate analogs.

O W Griffith, A Meister
PMCID: PMC431550  PMID: 20626

Abstract

Substrate analogs have been obtained that selectively inhibit the reactions of the gamma-glutamyl cycle or that are susceptible to only limited metabolism by the cycle. Thus, glutathione synthesis may be inhibited and analogs of glutathione may be synthesized that do not participate in transpeptidation. Specific inhibitors of gamma-glutamylcyclotransferase and 5-oxoprolinase have been obtained. The findings offer new approaches to the in vivo study of the cycle and also to the design of more specifically directed analogs of inhibitors such as methionine sulfoximine and 6-diazo-5-oxonorleucine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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