Skip to main content
PMC home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1976 Dec;73(12):4675–4679. doi: 10.1073/pnas.73.12.4675

Biological and serological characterization of radiation leukemia virus.

A Declève, M Lieberman, J N Ihle, H S Kaplan
PMCID: PMC431593  PMID: 188050

Abstract

Radiation leukemia virus, isolated from radiation-induced lymphomas in C57BL/Ka mice and propagated in that strain, is thymotropic and leukemogenic in vivo but replicates poorly, if at all, in mouse and mink fibroblast cultures in vitro. Comparative studies indicate that this naturally occurring virus is distinct from the previously recognized classes of endogenous murine ecotropic and xenotropic C-type viruses which are capable of replication on fibroblasts (fibrotropic) but are neither thymotropic nor leukemogenic. These studies also demonstrate that a differentiation-specific restriction system governing the replication of the murine ecotropic C-type viruses operates in addition to the previously defined Fv-1 and SRV gene restriction systems.

Full text

PDF
4675

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aaronson S. A., Stephenson J. R. Widespread natural occurrence of high titers of neutralizing antibodies to a specific class of endogenous mouse type-C virus. Proc Natl Acad Sci U S A. 1974 May;71(5):1957–1961. doi: 10.1073/pnas.71.5.1957. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Decleve A., Lieberman M., Niwa O., Kaplan H. S. Rapid in vivo assay for murine lymphatic leukaemia viruses. Nature. 1974 Nov 1;252(5478):79–81. doi: 10.1038/252079a0. [DOI] [PubMed] [Google Scholar]
  3. Declève A., Niwa O., Gelmann E., Kaplan H. S. Replication kinetics of N- and B-tropic murine leukemia viruses on permissive and nonpermissive cells in vitro. Virology. 1975 Jun;65(2):320–332. doi: 10.1016/0042-6822(75)90038-0. [DOI] [PubMed] [Google Scholar]
  4. Declève A., Niwa O., Hilgers J., Kaplan H. S. An improved murine leukemia virus immunofluorescence assay. Virology. 1974 Feb;57(2):491–502. doi: 10.1016/0042-6822(74)90188-3. [DOI] [PubMed] [Google Scholar]
  5. Declève A., Niwa O., Kojola J., Kaplan H. S. New gene locus modifying susceptibility to certain B-tropic murine leukemia viruses. Proc Natl Acad Sci U S A. 1976 Feb;73(2):585–590. doi: 10.1073/pnas.73.2.585. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Declève A., Sato C., Lieberman M., Kaplan H. S. Selective thymic localization of murine leukemia virus-related antigens in C57BL-Ka mice after inoculation with radiation virus. Proc Natl Acad Sci U S A. 1974 Aug;71(8):3124–3128. doi: 10.1073/pnas.71.8.3124. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Ferrer J. F., Kaplan H. S. Antigenic characteristics of lymphomas induced by radiation leukemia virus (RadLV) in mice and rats. Cancer Res. 1968 Dec;28(12):2522–2528. [PubMed] [Google Scholar]
  8. Fischinger P. J., Ihle J. N., Bolognesi D. P., Schäfer W. Inactivation of murine xenotropic oncornavirus by normal mouse sera is not immunoglobulin-mediated. Virology. 1976 May;71(1):346–351. doi: 10.1016/0042-6822(76)90118-5. [DOI] [PubMed] [Google Scholar]
  9. Fischinger P. J., Nomura S. Efficient release of murine xenotropic oncornavirus after murine leukemia virus infection of mouse cells. Virology. 1975 May;65(1):304–307. doi: 10.1016/0042-6822(75)90036-7. [DOI] [PubMed] [Google Scholar]
  10. Fischinger P. J., Sch5AAFER W., Bolognesi D. P. Neutralization of homologous and heterologous oncornaviruses by antisera against the p15(E) and gp71 polypeptides of Friend murine leukemia virus. Virology. 1976 May;71(1):169–184. doi: 10.1016/0042-6822(76)90103-3. [DOI] [PubMed] [Google Scholar]
  11. Haas M., Hilgers J. In vitro infection of lymphoid cells by thymotropic radiation leukemia virus grown in vitro. Proc Natl Acad Sci U S A. 1975 Sep;72(9):3546–3550. doi: 10.1073/pnas.72.9.3546. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Hartley J. W., Rowe W. P. Naturally occurring murine leukemia viruses in wild mice: characterization of a new "amphotropic" class. J Virol. 1976 Jul;19(1):19–25. doi: 10.1128/jvi.19.1.19-25.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Hino S., Stephenson J. R., Aaronson S. A. Radiommunoassays for the 70,000-molecular-weight glycoproteins of endogenous mouse type C viruses: viral antigen expression in normal mouse tissues and sera. J Virol. 1976 Jun;18(3):933–941. doi: 10.1128/jvi.18.3.933-941.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Ihle J. N., Denny T. P., Bolognesi D. P. Purification and serological characterization of the major envelope glycoprotein from AKR murine leukemia virus and its reactivity with autogenous immune sera from mice. J Virol. 1976 Mar;17(3):727–736. doi: 10.1128/jvi.17.3.727-736.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Ihle J. N., Hanna M. G., Jr, Roberson L. E., Kenney F. T. Autogenous immunity to endogenous RNA tumor virus. Identification of antibody reactivity to select viral antigens. J Exp Med. 1974 Jun 1;139(6):1568–1581. doi: 10.1084/jem.139.6.1568. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Kaplan H. S. On the natural history of the murine leukemias: presidential address. Cancer Res. 1967 Aug;27(8):1325–1340. [PubMed] [Google Scholar]
  17. LIEBERMAN M., KAPLAN H. S. Leukemogenic activity of filtrates from radiation-induced lymphoid tumors of mice. Science. 1959 Aug 14;130(3372):387–388. doi: 10.1126/science.130.3372.387. [DOI] [PubMed] [Google Scholar]
  18. Lee J. C., Hanna M. G., Jr, Ihle J. N., Aaronson S. A. Autogenous immunity to endogenous RNA tumor virus: differential reactivities of immunoglobulins M and G to virus envelope antigens. J Virol. 1974 Oct;14(4):773–781. doi: 10.1128/jvi.14.4.773-781.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Levy J. A., Ihle J. N., Oleszko O., Barnes R. D. Virus-specific neutralization by a soluble non-immunoglobulin factor found naturally in normal mouse sera. Proc Natl Acad Sci U S A. 1975 Dec;72(12):5071–5075. doi: 10.1073/pnas.72.12.5071. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Levy J. A. Xenotropic viruses: murine leukemia viruses associated with NIH Swiss, NZB, and other mouse strains. Science. 1973 Dec 14;182(4117):1151–1153. doi: 10.1126/science.182.4117.1151. [DOI] [PubMed] [Google Scholar]
  21. Lieber M. M., Sherr C. J., Todaro G. J. S-tropic murine type-C viruses: frequency of isolation from continuous cell lines, leukemia virus preparations and normal spleens. Int J Cancer. 1974 May 15;13(5):587–598. doi: 10.1002/ijc.2910130503. [DOI] [PubMed] [Google Scholar]
  22. Lieberman M., Niwa O., Declève A., Kaplan H. S. Continuous propagation of radiation leukemia virus on a C57BL mouse-embryo fibroblast line, with attenuation of leukemogenic activity. Proc Natl Acad Sci U S A. 1973 Apr;70(4):1250–1253. doi: 10.1073/pnas.70.4.1250. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Niwa O., Decléve A., Liberman M., Kaplan H. S. Adaptation of plaque assay methods to the in vitro quantitation of the radiation leukemia virus. J Virol. 1973 Jul;12(1):68–73. doi: 10.1128/jvi.12.1.68-73.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Odaka T. Genetic transmission of endogenous N- and B-tropic murine leukemia viruses in low-leukemic strain C57BL/6. J Virol. 1975 Feb;15(2):332–337. doi: 10.1128/jvi.15.2.332-337.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Old L. J., Boyse E. A., Stockert E. The G (Gross) leukemia antigen. Cancer Res. 1965 Jul;25(6):813–819. [PubMed] [Google Scholar]
  26. Pincus T., Hartley J. W., Rowe W. P. A major genetic locus affecting resistance to infection with murine leukemia viruses. I. Tissue culture studies of naturally occurring viruses. J Exp Med. 1971 Jun 1;133(6):1219–1233. doi: 10.1084/jem.133.6.1219. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Pincus T., Rowe W. P., Lilly F. A major genetic locus affecting resistance to infection with murine leukemia viruses. II. Apparent identity to a major locus described for resistance to friend murine leukemia virus. J Exp Med. 1971 Jun 1;133(6):1234–1241. doi: 10.1084/jem.133.6.1234. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES