Abstract
The female germ cell stage of primary importance in radiation genetic hazards is the immature, arrested oocyte. In the mouse, this stage has a near zero or zero sensitivity to mutation induction by radiation. However, the application of these mouse results to women has been questioned on the ground that the mouse arrested oocytes are highly sensitive to killing by radiation, while the human cells are not; and, furthermore, that the mature and maturing oocytes in the mouse, which are resistant to killing, are sensitive to mutation induction. The present results have a 2-fold bearing on this problem. First, a more detailed analysis of oocyte-stage sensitivity to killing and mutation induction shows that there is no consistent correlation, either negative or positive, between the two. This indicates that the sensitivity to cell killing of the mouse immature oocyte may not be sufficient reason to prevent its use in predicting the mutational response of the human immature oocyte. Second, if the much more cautious assumption is made that the human arrested oocyte might be as mutationally sensitive as the most sensitive of all oocyte stages in the mouse, namely the maturing and mature ones, then the present data on the duration of these stages permit more accurate estimates than were heretofore possible on the mutational response of these stages to chronic irradiation.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Abrahamson S., Wolff S. Re-analysis of radiation-induced specific locus mutations in the mouse. Nature. 1976 Dec 23;264(5588):715–719. doi: 10.1038/264715a0. [DOI] [PubMed] [Google Scholar]
- Batchelor A. L., Phillips R. J., Searle A. G. The ineffectiveness of chronic irradiation with neutrons and gamma rays in inducing mutations in female mice. Br J Radiol. 1969 Jun;42(498):448–451. doi: 10.1259/0007-1285-42-498-448. [DOI] [PubMed] [Google Scholar]
- CARTER T. C. Radiation-induced gene mutation in adult female and foetal male mice. Br J Radiol. 1958 Aug;31(368):407–411. doi: 10.1259/0007-1285-31-368-407. [DOI] [PubMed] [Google Scholar]
- Cox B. D., Lyon M. F. X-ray induced dominant lethal mutations in mature and immature oocytes of guinea-pigs and golden hamsters. Mutat Res. 1975 Jun;28(3):421–436. doi: 10.1016/0027-5107(75)90236-5. [DOI] [PubMed] [Google Scholar]
- Lyon M. F., Phillips R. J. Specific locus mutation rates after repeated small radiation doses to mouse oocytes. Mutat Res. 1975 Dec;30(3):375–382. [PubMed] [Google Scholar]
- RUSSELL W. L. X-ray-induced mutations in mice. Cold Spring Harb Symp Quant Biol. 1951;16:327–336. doi: 10.1101/sqb.1951.016.01.024. [DOI] [PubMed] [Google Scholar]
- Russell W. L. Effect of the interval between irradiation and conception on mutation frequency in female mice. Proc Natl Acad Sci U S A. 1965 Dec;54(6):1552–1557. doi: 10.1073/pnas.54.6.1552. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Russell W. L., Russell L. B., Cupp M. B. DEPENDENCE OF MUTATION FREQUENCY ON RADIATION DOSE RATE IN FEMALE MICE. Proc Natl Acad Sci U S A. 1959 Jan;45(1):18–23. doi: 10.1073/pnas.45.1.18. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Searle A. G., Beechey C. V. Cytogenetic effects of X-rays and fission neutrons in female mice. Mutat Res. 1974 Aug;24(2):171–186. doi: 10.1016/0027-5107(74)90130-4. [DOI] [PubMed] [Google Scholar]
- Wolff S. Estimation of the effects of chemical mutagens: lessons from radiation genetics. Mutat Res. 1975 Nov;33(1 Spec No):95–102. doi: 10.1016/0027-5107(75)90050-0. [DOI] [PubMed] [Google Scholar]