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. 1977 Aug;74(8):3579–3581. doi: 10.1073/pnas.74.8.3579

Thyrotropin-releasing hormone-like material in the rat retina: changes due to environmental lighting.

J M Schaeffer, M J Brownstein, J Axelrod
PMCID: PMC431635  PMID: 20629

Abstract

Material reacting with an antibody to thyrotropin-releasing hormone (TRH) has been found to be present in the rat retina. The compound present in the retina cochromatographed with authentic TRH and most of its activity was lost when incubated with pyroglutamate aminopeptidase (L-pyroglutamyl-peptide hydrolase, EC 3.4.11.8), an enzyme that degrades TRH. The TRH-like activity in the rat retina was low during the night and high during the day. There was a 4-hr lag period after the lights were turned on before peak TRH levels were attained. A decrease in TRH was seen after 2 hr of darkness and the level of TRH was lowest after 4 hr of darkness. Retinal TRH is elevated by environmental lighting regardless of the time of the day. These findings suggest that TRH may be involved in retinal photorecptive mechanisms.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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