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. 1977 Dec;74(12):5333–5335. doi: 10.1073/pnas.74.12.5333

Spatial requirement for coupling of iodotyrosine residues to form thyroid hormones.

H J Cahnmann, J Pommier, J Nunez
PMCID: PMC431707  PMID: 271955

Abstract

A linear random copolymer of tyrosine and lysine and two synthetic oligopeptides containing two tyrosine residues in addition to lysine residues give thyroid hormone (thyroxine and triodothyronine) residues in good yield upon enzymatic iodination with thyroid peroxidase. These synthetic peptides may serve as simple models for thyroglobulin, the protein in which biosynthesis of the thyroid hormone takes place. For the formation of significant amounts of hormone, such model compounds must contain at least two properly spaced tyrosine residues.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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