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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1977 Sep;74(9):3810–3813. doi: 10.1073/pnas.74.9.3810

Molecular events and energy changes during the action potential.

D G Margineanu, E Schoffeniels
PMCID: PMC431740  PMID: 71734

Abstract

A novel interpretation of the existing data concerning the energy changes associated with nerve impulse propagation is proposed. The main conclusion is that the negative phrase ofthe initial heat of activity cannot be accounted for without recourse to conformational changes in membrane proteins. It stems from analyzing and computing the energy changes associated with ionic flows, capacitive currents, and structural changes in membrane gateways. A close quantitative agreement with microcalorimetric measurements was achieved.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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