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. 1977 Dec;74(12):5482–5486. doi: 10.1073/pnas.74.12.5482

Two distinct adenosine-sensitive sites on adenylate cyclase.

C Londos, J Wolff
PMCID: PMC431772  PMID: 271970

Abstract

The effects of adenosine and adenosine analogs on adenylate cyclases from several tissues have been examined. Two adenosine-reactive sites have been identified: (i) the "R" site, occupancy of which usually leads to activation of cyclase and which requires integrity of the ribose ring for activity, and (ii) the "P" site, which mediates inhibition and requires integrity of the purine ring for activity. Biphasic effects of adenosine are explained by the presence of both sites on a single adenylate cyclase. Comparison of these data with those in the literature indicates that adenosine-reactive "P" and "R" sites are present generally.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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