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. 1977 Sep;74(9):4029–4032. doi: 10.1073/pnas.74.9.4029

Specific receptors for des-Asp1-angiotensin II (("angiotensin III") in rat adrenals.

M A Devynck, M G Pernollet, P G Matthews, M C Khosla, F M Bumpus, P Meyer
PMCID: PMC431830  PMID: 198814

Abstract

The specific binding of angiotensin II and des-Asp1-angiotensin II ("angiotensin III") III") to rat adrenals was studied with the use of the tritiated peptides. The binding sites having maximal affinity for angiotensin II were characterized by an equilibrium dissociation constant of 3.3 to 5.2 X 10(-9) M. Angiotensin III was able to interact with these sites, and also with a class of sites with very high affinity, characterized by an equilibrium dissociation constant of 1 to 2 X 10(-10) M. These sites exhibited a greater affinity for the heptapeptide angiotensin III than for the octapeptide angiotensin II. These findings, together with the known potent aldosterone stimulating effect of angiotensin III and its presence in rat plasma, suggest that this heptapeptide could be the physiologically important steroidogenic angiotensin in this species.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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