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. 1977 Sep;74(9):4055–4058. doi: 10.1073/pnas.74.9.4055

Alteration of cellular adhesion by nerve growth factor.

D Schubert, C Whitlock
PMCID: PMC431843  PMID: 198815

Abstract

Nerve growth factor increases the initial rates of cell-substratum and cell-cell adhesion of sympathetic nerve cell clone PC12. It also stimulates adenosine 3':5'-cyclic monophosphate accumulation in the cells, and exogenous adenosine 3':5'-cyclic monophosphate increases cell-substratum adhesion. NGH-stimulated adhesion is energy dependent and cold-sensitive and does not require de novo protein synthesis. It is probably mediated by an effect of adenosine 3':5'-cyclic monophosphate on the plasma membrane. Stimulation of cellular adhesion may be the first step in NGF-initiated neurite outgrowth by sympathetic nerve cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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