Skip to main content
NCBI home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1977 Oct;74(10):4296–4300. doi: 10.1073/pnas.74.10.4296

New pathway for the metabolism of pentitols

Jack London 1, Nina M Chace 1
PMCID: PMC431927  PMID: 16592445

Abstract

Certain strains of Lactobacillus casei can grow at the expense of one or more pentitols. These microorganisms possess a pentitol phosphate pathway that appears to be analogous to the hexitol phosphate pathway found in many facultatively anaerobic bacteria. Pentitol is transported into the cell by a phospho enolpyruvate phosphotransferase system that converts it to pentitol phosphate, whereupon a specific dehydrogenase oxidizes the intermediate product to ketopentose phosphate. The ketopentose phosphate is subsequently converted to xylulose-5-P and enters one of the pathways of central metabolism.

Keywords: pentitol phosphate, lactobacilli

Full text

PDF
4296

Images in this article

4299Image
on p.4299

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andrews K. J., Lin E. C. Selective advantages of various bacterial carbohydrate transport mechanisms. Fed Proc. 1976 Aug;35(10):2185–2189. [PubMed] [Google Scholar]
  2. Berkowitz D. D-Mannitol utilization in Salmonella typhimurium. J Bacteriol. 1971 Jan;105(1):232–240. doi: 10.1128/jb.105.1.232-240.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. HORWITZ S. B., KAPLAN N. O. HEXITOL DEHYDROGENASES OF BACILLUS SUBTILIS. J Biol Chem. 1964 Mar;239:830–838. [PubMed] [Google Scholar]
  4. KUNDIG W., GHOSH S., ROSEMAN S. PHOSPHATE BOUND TO HISTIDINE IN A PROTEIN AS AN INTERMEDIATE IN A NOVEL PHOSPHO-TRANSFERASE SYSTEM. Proc Natl Acad Sci U S A. 1964 Oct;52:1067–1074. doi: 10.1073/pnas.52.4.1067. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Lin E. C. The genetics of bacterial transport systems. Annu Rev Genet. 1970;4:225–262. doi: 10.1146/annurev.ge.04.120170.001301. [DOI] [PubMed] [Google Scholar]
  6. MORTLOCK R. P., WOOD W. A. METABOLISM OF PENTOSES AND PENTITOLS BY AEROBACTER AEROGENES. I. DEMONSTRATION OF PENTOSE ISOMERASE, PENTULOKINASE, AND PENTITOL DEHYDROGENASE ENZYME FAMILIES. J Bacteriol. 1964 Oct;88:838–844. doi: 10.1128/jb.88.4.838-844.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Maryanski J. H., Wittenberger C. L. Mannitol transport in Streptococcus mutans. J Bacteriol. 1975 Dec;124(3):1475–1481. doi: 10.1128/jb.124.3.1475-1481.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Patni N. J., Alexander J. K. Catabolism of fructose and mannitol in Clostridium thermocellum: presence of phosphoenolpyruvate: fructose phosphotransferase, fructose 1-phosphate kinase, phosphoenolpyruvate: mannitol phosphotransferase, and mannitol 1-phosphate dehydrogenase in cell extracts. J Bacteriol. 1971 Jan;105(1):226–231. doi: 10.1128/jb.105.1.226-231.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Tanaka S., Lerner S. A., Lin E. C. Replacement of a phosphoenolpyruvate-dependent phosphotransferase by a nicotinamide adenine dinucleotide-linked dehydrogenase for the utilization of mannitol. J Bacteriol. 1967 Feb;93(2):642–648. doi: 10.1128/jb.93.2.642-648.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Yamanaka K., Sakai S. Production of polyol dehydrogenases in bacteria. Can J Microbiol. 1968 Apr;14(4):391–396. doi: 10.1139/m68-062. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES