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. 1977 Oct;74(10):4458–4461. doi: 10.1073/pnas.74.10.4458

Microviscosity modulation during the cell cycle of neuroblastoma cells.

S W de Laat, P T van der Saag, M Shinitzky
PMCID: PMC431962  PMID: 270690

Abstract

Microviscosity (n) of the cell membrane lipid layer was determined in synchronized C1300 mouse neuroblastoma cells (clone Neuro-2A) by fluorescence polarization of 1,6-diphenystratum. The determined n value was maximal in mitosis, decreased markedly in the G1 phase, remained constant at a low level during the S phase, and increased again during the G2 phase. These findings imply a direct role of the cell membrane fluidity in regulation of the cell cycle.

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Selected References

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