Fig. 6.

KCl-induced calcium responses are decreased by paroxetine. (a) Shown is cytosolic calcium imaging. Rat hippocampal neurons were pretreated with 10 μM paroxetine for 1 hour before they were stimulated with 40 mM potassium chloride (KCl) to induce depolarization. KCl-evoked calcium responses in neurons were decreased by pretreatment cultures with paroxetine. (b) The peak amplitudes of depolarization-evoked calcium responses were significantly reduced in neurons pre-incubated with 10 μM paroxetine. Values represent mean ± SD (3–5 experiments per condition, *p <0.05, Student’s t-test)