Table 2.
Comparison in Linear Regression Analyses Between All Participants with 3,5-T2 Serum Concentrations >0.2 nM (Whole) and a Euthyroid Subpopulation
| Whole | Euthyroid | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Characteristics | Log-scale | N | βlin [95% CI]* | p | βspline [95% CI]** | p | N | βlin [95% CI]* | p | βspline [95% CI]** | p |
| TSH, mIU/L | Yes | 573 | −0.56 [−1.02, −0.11] | 0.02 | 1.30 [0.11, 2.49] | 0.03 | 487 | −0.10 [−0.26, 0.06] | 0.22 | — | — |
| Body mass index, kg/m2 | No | 573 | 0.28 [−0.32, 0.88] | 0.37 | — | — | 487 | −0.23 [−1.65, 1.19] | 0.75 | — | — |
| Waist circumference, cm | No | 573 | 0.18 [−1.29, 1.65] | 0.81 | — | — | 487 | −2.14 [−5.58, 1.31] | 0.22 | — | — |
| Waist-to-height ratio | No | 573 | 0.001 [−0.007, 0.010] | 0.75 | — | — | 487 | −0.016 [−0.037, 0.004] | 0.12 | — | — |
| Visceral fat, L | Yes | 502 | 0.01 [−0.07, 0.09] | 0.83 | — | — | 423 | −0.07 [−0.26, 0.13] | 0.52 | — | — |
| Subcutaneous fat, L | Yes | 502 | 0.02 [−0.04, 0.09] | 0.44 | — | — | 423 | 0.09 [−0.06, 0.23] | 0.26 | — | — |
| HDL cholesterol, mmol/L | No | 573 | −0.02 [−0.07, 0.03] | 0.45 | — | — | 487 | −0.01 [−0.12, 0.10] | 0.84 | — | — |
| LDL cholesterol, mmol/L | No | 573 | −0.07 [−0.20, 0.05] | 0.26 | — | — | 487 | −0.13 [−0.42, 0.16] | 0.38 | — | — |
| Total cholesterol, mmol/L | No | 573 | −0.12 [−0.26, 0.03] | 0.12 | — | — | 487 | −0.20 [−0.54, 0.13] | 0.24 | — | — |
| Total triglycerides, mmol/L | Yes | 573 | −0.04 [−0.11, 0.03] | 0.26 | — | — | 487 | −0.08 [−0.24, 0.07] | 0.31 | — | — |
| Vaspin, ng/dL | Yes | 536 | 0.08 [−0.06, 0.23] | 0.27 | — | — | 454 | 0.28 [−0.06, 0.62] | 0.10 | — | — |
| Leptin, ng/dL | Yes | 561 | 0.02 [−0.07, 0.12] | 0.66 | — | — | 475 | −0.05 [−0.28, 0.17] | 0.64 | — | — |
| Serum glucose, mmol/L | No | 573 | 0.46 [0.01, 0.91] | 0.05 | −1.40 [−2.56, −0.23] | 0.02 | 487 | 0.82 [0.08, 1.57] | 0.03 | −4.10 [−7.89, −0.31] | 0.03 |
| HbA1c, % | No | 573 | 0.004 [−0.077, 0.086] | 0.92 | — | — | 487 | −0.12 [−0.31, 0.08] | 0.23 | — | — |
| HOMA-IR | Yes | 573 | 0.001 [−0.098, 0.100] | 0.98 | — | — | 487 | 0.02 [−0.21, 0.25] | 0.85 | — | — |
| Insulin, μIU/mL | Yes | 313 | 0.10 [−0.06, 0.27] | 0.22 | — | — | 269 | −0.03 [−0.29, 0.23] | 0.81 | — | — |
Log-scale indicates whether the dependent variable was transformed by natural logarithm before analysis.
*
Multivariate linear regression model adjusted for age and sex; **additional variable if 3,5-T2 concentrations were modeled by means of restricted cubic splines (appears only when the usage of splines represented a gain in model quality assessed by a likelihood ratio test).