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. 1975 Jan;72(1):152–156. doi: 10.1073/pnas.72.1.152

Nonrandom chromosomal abnormalities in hematologic disorders of man.

J D Rowley
PMCID: PMC432260  PMID: 1054491

Abstract

A nonrandom pattern of chromosomal abnormalities occurs in bone marrow cells obtained from patients with hematologic disorders who have an abnormal karyotype involving a C group chromosome. An additional number 8 chromosome is the most common abnormality, found in more than one-half of the patients studies. An additional number 9 chromosome and the loss of all or part of a number 7 are abnormalities that occur more often than might be expected by chance. It is proposed that specific human chromosomal abnormalities may be related to different specific etiologic agents.

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Selected References

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