Skip to main content
NCBI home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1975 Mar;72(3):834–836. doi: 10.1073/pnas.72.3.834

D-amphetamine disaggregates brain polysomes via a dopaminergic mechanism.

M A Moskowitz, B F Weiss, L D Lytle, H N Munro, J Wurtman
PMCID: PMC432414  PMID: 1055379

Abstract

Brain polysomes are disaggregated in rats given moderate to large doses of d-amphetamine sulfate; this response is rapid in onset, lasts for at least 4-6 hr, and varies with the age of the animal. Pretreatment with a dopamine receptor blocking agent, haloperidol or pimozide, blocks the amphetamine-induced disaggregation.

Full text

PDF
834

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ADLER M. W. Changes in sensitivity to amphetamine in rats with chronic brain lesions. J Pharmacol Exp Ther. 1961 Nov;134:214–221. [PubMed] [Google Scholar]
  2. Andén N. E., Dahlström A., Fuxe K., Larsson K. Functional role of the nigro-neostriatal dopamine neurons. Acta Pharmacol Toxicol (Copenh) 1966;24(2):263–274. doi: 10.1111/j.1600-0773.1966.tb00389.x. [DOI] [PubMed] [Google Scholar]
  3. CARLSSON A., LINDQVIST M. EFFECT OF CHLORPROMAZINE OR HALOPERIDOL ON FORMATION OF 3METHOXYTYRAMINE AND NORMETANEPHRINE IN MOUSE BRAIN. Acta Pharmacol Toxicol (Copenh) 1963;20:140–144. doi: 10.1111/j.1600-0773.1963.tb01730.x. [DOI] [PubMed] [Google Scholar]
  4. Davis W. M., Logston D. G., Hickenbottom J. P. Antagonism of acute amphetamine intoxication by haloperidol and propranolol. Toxicol Appl Pharmacol. 1974 Sep;29(3):397–403. doi: 10.1016/0041-008x(74)90112-4. [DOI] [PubMed] [Google Scholar]
  5. Dingell J. V., Owens M. L., Norvich M. R., Sulser F. On the role of norepinephrine biosynthesis in the central action of amphetamine. Life Sci. 1967 Jun 1;6(11):1155–1162. doi: 10.1016/0024-3205(67)90197-x. [DOI] [PubMed] [Google Scholar]
  6. Dolfini E., Ramirez del Angel A., Garattini S., Valzelli L. Brain catecholamine release by dexamphetamine in three strains of mice. Eur J Pharmacol. 1970 Mar;9(3):333–336. doi: 10.1016/0014-2999(70)90231-1. [DOI] [PubMed] [Google Scholar]
  7. Dolfini E., Tansella M., Valzelli L., Garattini S. Further studies on the interaction between desipramine and amphetamine. Eur J Pharmacol. 1969 Jan;5(2):185–190. doi: 10.1016/0014-2999(69)90028-4. [DOI] [PubMed] [Google Scholar]
  8. GLOWINSKI J., AXELROD J. EFFECT OF DRUGS ON THE UPTAKE, RELEASE, AND METABOLISM OF H3-NOREPINEPHRINE IN THE RAT BRAIN. J Pharmacol Exp Ther. 1965 Jul;149:43–49. [PubMed] [Google Scholar]
  9. Hutchins D. A., Rogers K. J. Effect of depletion of cerebral monoamines on the concentration of glycogen and on amphetamine-induced glycogenolysis in the brain. Br J Pharmacol. 1973 May;48(1):19–29. doi: 10.1111/j.1476-5381.1973.tb08218.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Loh H., Hitzemann R., Stolman S. Effect of d-amphetamine on brain protein synthesis. Toxicol Appl Pharmacol. 1973 Nov;26(3):476–481. doi: 10.1016/0041-008x(73)90284-6. [DOI] [PubMed] [Google Scholar]
  11. Munro H. N., Roel L., Wurtman R. J. Inhibition of brain protein synthesis by doses of L-DOPA that disaggregate brain polyribosomes. J Neural Transm. 1973;34(4):321–323. doi: 10.1007/BF01242753. [DOI] [PubMed] [Google Scholar]
  12. Randrup A., Scheel-Krüger J. Diethyldithiocarbamate and amphetamine stereotype behavior. J Pharm Pharmacol. 1966 Nov;18(11):752–752. doi: 10.1111/j.2042-7158.1966.tb07799.x. [DOI] [PubMed] [Google Scholar]
  13. Roel L. E., Schwartz S. A., Weiss B. F., Munro H. N., Wurtman R. J. In vivo inhibition of rat brain protein synthesis by L-dopa. J Neurochem. 1974 Jul;23(1):233–239. doi: 10.1111/j.1471-4159.1974.tb06939.x. [DOI] [PubMed] [Google Scholar]
  14. Rogers K. J., Hutchins D. A. Studies on the relation of chemical structure to glycogenolytic activity in the brain. Eur J Pharmacol. 1972 Oct;20(1):97–103. doi: 10.1016/0014-2999(72)90221-x. [DOI] [PubMed] [Google Scholar]
  15. Rutledge C. O. The mechanisms by which amphetamine inhibits oxidative deamination of norepinephrine in brain. J Pharmacol Exp Ther. 1970 Feb;171(2):188–195. [PubMed] [Google Scholar]
  16. SMITH C. B. EFFECTS OF D-AMPHETAMINE UPON BRAIN AMINE CONTENT AND LOCOMOTOR ACTIVITY OF MICE. J Pharmacol Exp Ther. 1965 Jan;147:96–102. [PubMed] [Google Scholar]
  17. Scheel-Krüger J. Comparative studies of various amphetamine analogues demonstrating different interactions with the metabolism of the catecholamines in the brain. Eur J Pharmacol. 1971;14(1):47–59. doi: 10.1016/0014-2999(71)90121-x. [DOI] [PubMed] [Google Scholar]
  18. Weiss B. F., Munro H. N., Ordonez L. A., Wurtman R. J. Dopamine: mediator of brain polysome disaggregation after L-dopa. Science. 1972 Aug 18;177(4049):613–616. doi: 10.1126/science.177.4049.613. [DOI] [PubMed] [Google Scholar]
  19. Weiss B. F., Munro H. N., Wurtman R. J. L-dopa: disaggregation of brain polysomes and elevation of brain tryptophan. Science. 1971 Aug 27;173(3999):833–835. doi: 10.1126/science.173.3999.833. [DOI] [PubMed] [Google Scholar]
  20. Yehuda S., Wurtman R. J. Release of brain dopamine as the probable mechanism for the hypothermic effect of D-amphetamine. Nature. 1972 Dec 22;240(5382):477–478. doi: 10.1038/240477a0. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES