FIG 7 .

Average magnitudes of deviation in genome-wide transcript levels of essential, core, and accessory genes in rpoB mutants D521G and H531R relative to the levels in the ancestral strain. The 4,765 genes of the P. aeruginosa PAO1 genome that were successfully sequenced in our RNA-Seq dataset were classified as essential, core, and accessory genes. Regardless of the classification of genes, the average magnitudes of deviation in relative transcript levels are significantly greater in the H531R rpoB mutant than in the D521G mutant (two-tailed, two-sample t test: *, P < 0.05).