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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1975 Apr;72(4):1354–1358. doi: 10.1073/pnas.72.4.1354

Proposal concerning mechanism of evolution of the genome of Escherichia coli.

D Zipkas, M Riley
PMCID: PMC432532  PMID: 1093179

Abstract

Many pairs of genes whose gene products are functionally related lie either 90 degrees or 180 degrees apart on the circular map of the E. coli chromosome. A mechanism of evolution is proposed that involves two sequential duplications of an ancestral genome, followed by mutation and divergence of function of replicate genes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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