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. 1975 Apr;72(4):1420–1424. doi: 10.1073/pnas.72.4.1420

Estrogen-directed synthesis of specific prostaglandins in uterus.

E A Ham, V J Cirillo, M E Zanetti, F A Kuehl Jr
PMCID: PMC432546  PMID: 165507

Abstract

Endogenous uterine prostaglandin levels were monitored in the cycling rat and prostaglandins of the F-type were found to rise at proestrus when estrogen levels have been shown to be maximal. Evidence that this is an estrogen-induced event is furnished by the finding that estradiol-17beta caused a similar rise in prostaglandin F levels in uteri of ovariectomized rats, an action blocked by coadministration of progesterone. Examination of in vitro prostaglandin synthetase by uterine microsomal fractions from cycling rats and estrogen-treated ovariectomized rats revealed that the action of estrogen to control prostaglandin synthesis in a directional manner is accomplished, at least in part, by regulation of the prostaglandin synthetase complex, resulting in a patterned alteration in the ratio of prostaglandin F to prostaglandin E. These results demonstrate that prostaglandins are involved in the expression of estrogen action in the rat uterus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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