Abstract
The binding of ligands by a macromolecule can be well described by a group of potentials derivable from the energy and of which the original binding potential is one. The group is Abelian and is isomorphic with a group of symmetries. Each member corresponds to a particular set of experimental conditions--system open to some, closed to others, of the ligand-and the group as a whole is an immediate source of all possible linkage relations applicable to the macromolecule. Seen in terms of information theory it can be interpreted as a program for the response of the macromolecule to its ligands according to the conditions with which it is faced. The group provides a ready formulation of the effect of a ligand on the equilibrium constant for a reaction involving a set of macromolecules, and it leads to a clear-cut distinction between true and pseudolinkage.
Full text
PDF




Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Heck H. D. A general derivation of the binding potential. J Mol Biol. 1970 Jun 28;50(3):703–705. doi: 10.1016/0022-2836(70)90094-x. [DOI] [PubMed] [Google Scholar]
- Heck H. D. Statistical theory of cooperative binding to proteins. The Hill equation and the binding potential. J Am Chem Soc. 1971 Jan 13;93(1):23–29. doi: 10.1021/ja00730a004. [DOI] [PubMed] [Google Scholar]
- WYMAN J. THE BINDING POTENTIAL, A NEGLECTED LINKAGE CONCEPT. J Mol Biol. 1965 Mar;11:631–644. doi: 10.1016/s0022-2836(65)80017-1. [DOI] [PubMed] [Google Scholar]
- Wyman J., Phillipson P. E. A probabilistic approach to cooperativity of ligand binding by a polyvalent molecule. Proc Natl Acad Sci U S A. 1974 Sep;71(9):3431–3434. doi: 10.1073/pnas.71.9.3431. [DOI] [PMC free article] [PubMed] [Google Scholar]