Abstract
Rabbit pups had one eye sutured closed before the time at which the eyes normally open. At 20-27 days of age, single-unit recordings were made both from the striate cortex contralateral to the sutured eye (deprived cortex) and from that contralateral to the eye which had opened normally (control cortex). The percentages of units encountered which fell into various receptive field categories differed on the two sides. The deprived cortices had a lower percentage of visually responsive cells, a higher percentage of indefinite cells, and totally lacked cells sensitive to orientation of a stimulus bar. In these respects they closely resembled previous observations on rabbit pups just before normal eye-opening. By contrast, the control cortices of the same animals were comparable to normally reared rabbits of the same age. We conclude, therefore, that developmental events which normally follow eye-opening can be affected in their time course by delaying eye-opening.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Barlow H. B., Pettigrew J. D. Lack of specificity of neurones in the visual cortex of young kittens. J Physiol. 1971 Oct;218 (Suppl):98P–100P. [PubMed] [Google Scholar]
- Blakemore C., Van Sluyters R. C. Reversal of the physiological effects of monocular deprivation in kittens: further evidence for a sensitive period. J Physiol. 1974 Feb;237(1):195–216. doi: 10.1113/jphysiol.1974.sp010478. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chow K. L., Masland R. H., Stewart D. L. Receptive field characteristics of striate cortical neurons in the rabbit. Brain Res. 1971 Oct 29;33(2):337–352. doi: 10.1016/0006-8993(71)90107-7. [DOI] [PubMed] [Google Scholar]
- Chow K. L., Spear P. D. Morphological and functional effects of visual deprivation on the rabbit visual system. Exp Neurol. 1974 Feb;42(2):429–447. doi: 10.1016/0014-4886(74)90036-3. [DOI] [PubMed] [Google Scholar]
- Grobstein P., Chow K. L., Spear P. D., Mathers L. H. Development of rabbit visual cortex: late appearance of a class of receptive fields. Science. 1973 Jun 15;180(4091):1185–1187. doi: 10.1126/science.180.4091.1185. [DOI] [PubMed] [Google Scholar]
- Hubel D. H., Wiesel T. N. Binocular interaction in striate cortex of kittens reared with artificial squint. J Neurophysiol. 1965 Nov;28(6):1041–1059. doi: 10.1152/jn.1965.28.6.1041. [DOI] [PubMed] [Google Scholar]
- Mathers L. H., Chow K. L., Spear P. D., Grobstein P. Ontogenesis of receptive fields in the rabbit striate cortex. Exp Brain Res. 1974 Jan 22;19(1):20–35. doi: 10.1007/BF00233393. [DOI] [PubMed] [Google Scholar]
- Mize R. R., Murphy E. H. Selective visual experience fails to modify receptive field properties of rabbit striate cortex neurons. Science. 1973 Apr 20;180(4083):320–323. doi: 10.1126/science.180.4083.320. [DOI] [PubMed] [Google Scholar]
- Pettigrew J. D. The effect of visual experience on the development of stimulus specificity by kitten cortical neurones. J Physiol. 1974 Feb;237(1):49–74. doi: 10.1113/jphysiol.1974.sp010469. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Van Sluyters R. C., Stewart D. L. Binocular neurons of the rabbit's visual cortex: effects of monocular sensory deprivation. Exp Brain Res. 1974 Jan 31;19(2):196–204. doi: 10.1007/BF00238534. [DOI] [PubMed] [Google Scholar]
- WIESEL T. N., HUBEL D. H. SINGLE-CELL RESPONSES IN STRIATE CORTEX OF KITTENS DEPRIVED OF VISION IN ONE EYE. J Neurophysiol. 1963 Nov;26:1003–1017. doi: 10.1152/jn.1963.26.6.1003. [DOI] [PubMed] [Google Scholar]