Abstract
Glyoxal and methylglyoxal interact with biogenic amines and form biologically active free radicals. Electron spin resonance absorption of the radical at room temperature is characterized by a signal at g equals 2.004 with peak-to-peak width of 29 G. An optical absorption at 400 nm with molar absorptivity of 23,000 accompanies the formation of the radical. The dry powdered preparation of the same reaction, which is considered to be the seconardy product, gives an electron spin resonance signal much narrower and 1/200 in intensity compared with the one in solution. Similarly the 400 nm absorption intensity is 1/8 that of the primary product. Possible biological significance of the primary and the secondary product, in relation to muscular dystrophy and photophosphorylation, is discussed.
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Selected References
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- Anderson T. W. Nutritional muscular dystrophy and human myocardial infarction. Lancet. 1973 Aug 11;2(7824):298–302. doi: 10.1016/s0140-6736(73)90798-8. [DOI] [PubMed] [Google Scholar]
- Cotzias G. C., Papavasiliou P. S., Gellene R. Modification of Parkinsonism--chronic treatment with L-dopa. N Engl J Med. 1969 Feb 13;280(7):337–345. doi: 10.1056/NEJM196902132800701. [DOI] [PubMed] [Google Scholar]
- Cotzias G. C., Van Woert M. H., Schiffer L. M. Aromatic amino acids and modification of parkinsonism. N Engl J Med. 1967 Feb 16;276(7):374–379. doi: 10.1056/NEJM196702162760703. [DOI] [PubMed] [Google Scholar]
- Parker J. M., Mendell J. R. Proximal myopathy induced by 5-HT-imipramine simulates Duchenne dystrophy. Nature. 1974 Jan 11;247(5436):103–104. doi: 10.1038/247103b0. [DOI] [PubMed] [Google Scholar]
- SCHAUENSTEIN E., ZANGGER J., RATZENHOFER M. UBER DIE WIRKUNG VON HYDROXYOCTENAL AUF EHRLICH-ASCITES-TUMORZELLEN. Z Naturforsch B. 1964 Oct;19:923–929. [PubMed] [Google Scholar]
- Schauenstein E. Autoxidation of polyunsaturated esters in water: chemical structure and biological activity of the products. J Lipid Res. 1967 Sep;8(5):417–428. [PubMed] [Google Scholar]
- Szent-Györgyi A. Electronic biology and its relation to cancer. Life Sci. 1974 Sep 1;15(5):863–875. doi: 10.1016/0024-3205(74)90003-4. [DOI] [PubMed] [Google Scholar]