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. 1975 May;72(5):1782–1786. doi: 10.1073/pnas.72.5.1782

Cooperative activation of action potential Na+ ionophore by neurotoxins.

W A Catterall
PMCID: PMC432630  PMID: 1057169

Abstract

Four neurotoxins that activate the action potential Na+ ionophore of electrically excitable neuroblastoma cells interact with two distinct classes of sites, one specific for the alkaloids veratridine, batrachotoxin, and aconitine, and the second specific for scorpion toxin. Positive heterotropic cooperativity is observed between toxins bound at these two classes of sites. Tetrodotoxin is a noncompetitive inhibitor of activation by each of these toxins (KI = 4-8 nM). These results suggest the existence of three functionally separable components of the action potential Na+ ionophore: two regulatroy components, which bind activating neurotoxins and interact allosterically in controlling the activity of a third ion-transport component, which binds tetrodotoxin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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