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. 1975 May;72(5):1843–1847. doi: 10.1073/pnas.72.5.1843

Folding of the DNA double helix in chromatin-like structures from simian virus 40.

J E Germond, B Hirt, P Oudet, M Gross-Bellark, P Chambon
PMCID: PMC432643  PMID: 168578

Abstract

Relaxed circular, covalently closed simian virus 40 DNA molecules were associated with the four histones that are present in virions. In electron micrographs the resulting complexes appear twisted, with globular structures (nucleosomes) along the DNA. Incubation with an untwisting extract converts the twisted complexes to relaxed structures. Extraction of the DNA from the relaxed complexes yields supercoiled molecules. The number of superhelical turns in these molecules corresponds to the number of nucleosomes per DNA molecule in the complexes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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