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. 1975 May;72(5):1895–1898. doi: 10.1073/pnas.72.5.1895

Secretion of a nerve growth factor by mouse neuroblastoma cells in culture.

R A Murphy, N J Pantazis, B G Arnason, M Young
PMCID: PMC432654  PMID: 1057179

Abstract

Analyses of supernatant solutions from mouse C1300 neuroblastoma cultures by two independent immunoassays reveal that these cells secrete a factor which is immunochemically similar to mouse submaxillary gland nerve growth factor. The neuroblastoma factor is also biologically active in inducing neurite outgrowth from embryonic sensory ganglia-an effect that is completely blocked by specific antibody to nerve growth factor. Neuroblastoma cells are known to be functionally responsive to nerve growth factor, and the observation that they secrete a molecule like it may mean that these cells require or utilize the factor during growth in culture.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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