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. 1975 Jun;72(6):2091–2094. doi: 10.1073/pnas.72.6.2091

Lymphokine-induced production and release of lysosomal enzymes by macrophages.

R M Pantalone, R C Page
PMCID: PMC432701  PMID: 1056016

Abstract

MACROPHAGES ARE ASSOCIATED WITH MOST CHRONIC INFLAMMATORY LESIONS, AND THESE CELLS CONTAIN ENZYMES THAT ARE ABLE TO DESTROY CONNECTIVE TISSUE CONSTITUENTS. Normal lymphoid cells responding to a mitogen, phytohemagglutinin-P, release factor(s) that cause a marked increase in the size and enzyme content for mononuclear phagocytes maintained in culture. The stimulated macrophages, which by several criteria remain otherwise viable and healthy, selectively release large quantities of hydrolytic enzymes to the culture medium.

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Selected References

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