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. 1975 Jun;72(6):2265–2269. doi: 10.1073/pnas.72.6.2265

Early effect of interferon on mouse leukemia cells cultivated in a chemostat.

M Tovey, D Brouty-Boyé, I Gresser
PMCID: PMC432738  PMID: 1056030

Abstract

Mouse interferon preparations inhibited the multiplication of mouse leukemia L 1210 cells cultivated under steady-state conditions in a chemostat. The use of this sensitive and controlled system led to the detection of a rapid inhibition in the incorporation of (3-H)thymidine into cellular acid-precipitable material 2 hr after the addition of interferon, whereas an effect on cell multiplication was not detected until 22 hr later. Interferon exerted only a transitory effect on the incorporation of (3-H)uridine into acid-precipitable material and no effect on the incorporation of 14-C-amino acids into cellular protein. It is suggested that the chemostat offers many advantages for the investigation of those physiologic factors or chemotherapeutic substances that modify cell division.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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