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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1975 Jul;72(7):2635–2639. doi: 10.1073/pnas.72.7.2635

Isolation of a cationic polypeptide from human serum that stimulates proliferation of 3T3 cells.

H N Antoniades, D Stathakos, C D Scher
PMCID: PMC432824  PMID: 1058478

Abstract

A basic polypeptide that stimulates DNA synthesis and cell division in confluent populations of mouse Balb/c-3T3 cells has been isolated from whole human serum, and has been separated from the heterogenous group of molecules with insulin-like activity. This highly purified basic polypeptide has a molecular weight of 1.3 x 10(4) and an isoelectric point of 9.7. Approximately 10(7) polypeptide molecules in the growth medium allow the replication of one density-inhibited cell.

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Selected References

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