Skip to main content
PMC home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1975 Jul;72(7):2819–2823. doi: 10.1073/pnas.72.7.2819

Somnolence, akinesia, and sensory activation of motivated behavior in the lateral hypothalamic syndrome.

D R Levitt, P Teitelbaum
PMCID: PMC432863  PMID: 1101268

Abstract

After lateral hypothalamic damage in rats, somnolence, akinesia, and sensory neglect combine to produce complete aphagia. Only simple automatisms (such as grooming, chewing, licking) are present, but intense stimuli can activate more complex actions (walking, orientation, swimming). In the anorexic stage, tactile stimuli dominate in steering locomotion and "spontaneous" locomotion depends on activation from the empty stomach.

Full text

PDF
2819

Images in this article

2820Image
on p.2820
2820Image
on p.2820
2820Image
on p.2820
2820Image
on p.2820
2822Image
on p.2822
2822Image
on p.2822
2822Image
on p.2822
2822Image
on p.2822

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANAND B. K., BROBECK J. R. Hypothalamic control of food intake in rats and cats. Yale J Biol Med. 1951 Nov;24(2):123–140. [PMC free article] [PubMed] [Google Scholar]
  2. Anchel H., Lindsley D. B. Differentiation of two reticulo-hypothalamic systems regulating hippocampal activity. Electroencephalogr Clin Neurophysiol. 1972 Mar;32(3):209–226. doi: 10.1016/0013-4694(72)90171-x. [DOI] [PubMed] [Google Scholar]
  3. BAILLIE P., MORRISON S. D. The nature of the suppression of food intake by lateral hypothalamic lesions in rats. J Physiol. 1963 Feb;165:227–245. doi: 10.1113/jphysiol.1963.sp007054. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cheng M. F., Rozin P., Teitelbaum P. Starvation retards development of food and water regulations. J Comp Physiol Psychol. 1971 Aug;76(2):206–218. doi: 10.1037/h0031374. [DOI] [PubMed] [Google Scholar]
  5. Epstein A. N., Teitelbaum P. Specific loss of the hypoglycemic control of feeding in recovered lateral rats. Am J Physiol. 1967 Nov;213(5):1159–1167. doi: 10.1152/ajplegacy.1967.213.5.1159. [DOI] [PubMed] [Google Scholar]
  6. Evetts K. D., Fitzsimons J. T., Setler P. E. Eating caused by 6-hydroxydopamine-induced release of noradrenaline in the diencephalon of the rat. J Physiol. 1972 May;223(1):35–47. doi: 10.1113/jphysiol.1972.sp009832. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Fentress J. C. Development of grooming in mice with amputated forelimbs. Science. 1973 Feb 16;179(4074):704–705. doi: 10.1126/science.179.4074.704. [DOI] [PubMed] [Google Scholar]
  8. Huston J. P., Borbély A. A. The thalamic rat: general behavior, operant learning with rewarding hypothalamic stimulation, and effects of amphetamine. Physiol Behav. 1974 Mar;12(3):433–448. doi: 10.1016/0031-9384(74)90121-8. [DOI] [PubMed] [Google Scholar]
  9. Kissileff H. R., Epstein A. N. Exaggerated prandial drinking in the "recovered lateral" rat without saliva. J Comp Physiol Psychol. 1969 Mar;67(3):301–308. doi: 10.1037/h0026775. [DOI] [PubMed] [Google Scholar]
  10. Marshall J. F., Teitelbaum P. A comparison of the eating in response to hypothermic and glucoprivic challenges after nigral 6-hydroxydopamine and lateral hypothalamic electrolytic lesions in rats. Brain Res. 1973 May 30;55(1):229–233. doi: 10.1016/0006-8993(73)90507-6. [DOI] [PubMed] [Google Scholar]
  11. Marshall J. F., Teitelbaum P. Further analysis of sensory inattention following lateral hypothalamic damage in rats. J Comp Physiol Psychol. 1974 Mar;86(3):375–395. doi: 10.1037/h0035941. [DOI] [PubMed] [Google Scholar]
  12. Marshall J. F., Turner B. H., Teitelbaum P. Sensory neglect produced by lateral hypothalamic damage. Science. 1971 Oct 29;174(4008):523–525. doi: 10.1126/science.174.4008.523. [DOI] [PubMed] [Google Scholar]
  13. McGinty D. J. Somnolence, recovery and hyposomnia following ventro-medial diencephalic lesions in the rat. Electroencephalogr Clin Neurophysiol. 1969 Jan;26(1):70–79. doi: 10.1016/0013-4694(69)90035-2. [DOI] [PubMed] [Google Scholar]
  14. Powley T. L., Keesey R. E. Relationship of body weight to the lateral hypothalamic feeding syndrome. J Comp Physiol Psychol. 1970 Jan;70(1):25–36. doi: 10.1037/h0028390. [DOI] [PubMed] [Google Scholar]
  15. REYNOLDS R. W. AN IRRITATIVE HYPOTHESIS CONCERNING THE HYPOTHALAMIC REGULATION OF FOOD INTAKE. Psychol Rev. 1965 Mar;72:105–116. doi: 10.1037/h0021815. [DOI] [PubMed] [Google Scholar]
  16. RODGERS W. L., EPSTEIN A. N., TEITELBAUM P. LATERAL HYPOTHALAMIC APHAGIA: MOTOR FAILURE OR MOTIVATIONAL DEFICIT? Am J Physiol. 1965 Feb;208:334–342. doi: 10.1152/ajplegacy.1965.208.2.334. [DOI] [PubMed] [Google Scholar]
  17. Robinson T. E., Whishaw I. Q. Effects of posterior hypothalamic lesions on voluntary behavior and hippocampal electroencephalograms in the rat. J Comp Physiol Psychol. 1974 May;86(5):768–786. doi: 10.1037/h0036397. [DOI] [PubMed] [Google Scholar]
  18. Robinson T. E., Whishaw I. Q., Wishart T. B. The effects of posterior hypothalamic lesions on swimming movements in different water temperatures by the rat. Can J Psychol. 1974 Mar;28(1):102–113. doi: 10.1037/h0081970. [DOI] [PubMed] [Google Scholar]
  19. Schapiro S., Salas M., Vukovich K. Hormonal effects on ontogeny of swimming ability in the rat: assessment of central nervous system development. Science. 1970 Apr 3;168(3927):147–150. doi: 10.1126/science.168.3927.147. [DOI] [PubMed] [Google Scholar]
  20. Sorenson C. A., Ellison G. D. Striatal organization of feeding behavior in the decorticate rat. Exp Neurol. 1970 Oct;29(1):162–174. doi: 10.1016/0014-4886(70)90047-6. [DOI] [PubMed] [Google Scholar]
  21. Stricker E. M., Wolf G. The effect of hypovolemia on drinking in rats with lateral hypothalamic damage. Proc Soc Exp Biol Med. 1967 Mar;124(3):816–820. doi: 10.3181/00379727-124-31860. [DOI] [PubMed] [Google Scholar]
  22. TEITELBAUM P., EPSTEIN A. N. The lateral hypothalamic syndrome: recovery of feeding and drinking after lateral hypothalamic lesions. Psychol Rev. 1962 Mar;69:74–90. doi: 10.1037/h0039285. [DOI] [PubMed] [Google Scholar]
  23. TEITELBAUM P., STELLAR E. Recovery from the failure to eat produced by hypothalamic lesions. Science. 1954 Nov 26;120(3126):894–895. doi: 10.1126/science.120.3126.894. [DOI] [PubMed] [Google Scholar]
  24. Teitelbaum P., Cheng M. F., Rozin P. Stages of recovery and development of lateral hypothalamic control of food and water intake. Ann N Y Acad Sci. 1969 May 15;157(2):849–860. doi: 10.1111/j.1749-6632.1969.tb12923.x. [DOI] [PubMed] [Google Scholar]
  25. Turner B. H. Sensorimotor syndrome produced by lesions of the amygdala and lateral hypothalamus. J Comp Physiol Psychol. 1973 Jan;82(1):37–47. doi: 10.1037/h0033803. [DOI] [PubMed] [Google Scholar]
  26. Ungerstedt U. Adipsia and aphagia after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system. Acta Physiol Scand Suppl. 1971;367:95–122. doi: 10.1111/j.1365-201x.1971.tb11001.x. [DOI] [PubMed] [Google Scholar]
  27. Vanderwolf C. H. Limbic-diencephalic mechanisms of voluntary movement. Psychol Rev. 1971 Mar;78(2):83–113. doi: 10.1037/h0030672. [DOI] [PubMed] [Google Scholar]
  28. Wayner M. J., Cott A., Millner J., Tartaglione R. Loss of 2-deoxy-D-glucose induced eating in recovered lateral rats. Physiol Behav. 1971 Dec;7(6):881–884. doi: 10.1016/0031-9384(71)90057-6. [DOI] [PubMed] [Google Scholar]
  29. Whishaw I. Q., Robinson T. E. Comparison of anodal and cathodal lesions and metal deposition in eliciting postoperative locomotion in the rat. Physiol Behav. 1974 Oct;13(4):539–551. doi: 10.1016/0031-9384(74)90285-6. [DOI] [PubMed] [Google Scholar]
  30. Whishaw I. Q., Vanderwolf C. H. Hippocampal EEG and behavior: effects of variation in body temperature and relation of EEG to vibrissae movement, swimming and shivering. Physiol Behav. 1971 Apr;6(4):391–397. doi: 10.1016/0031-9384(71)90172-7. [DOI] [PubMed] [Google Scholar]
  31. Zeigler H. P., Karten H. J. Central trigeminal structures and the lateral hypothalamic syndrome in the rat. Science. 1974 Nov 15;186(4164):636–638. doi: 10.1126/science.186.4164.636. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES