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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Pain. 2015 Mar;156(3):469–482. doi: 10.1097/01.j.pain.0000460333.79127.be

Figure 4. Pioglitazone did not produce ataxia or changes in transient nociception.

Figure 4

Motor coordination was assessed on an accelerating rotarod before and at 1, 2, and 3 h after high dose pioglitazone (Pio) administration by (A) systemic (i.p. 100 mg/kg) or (B) spinal (i.t. 1000 μg) routes. Pioglitazone did not change time spent on the accelerating rotarod. The analgesic effects of pioglitazone were tested using the Hargreaves assay before and after intrathecal saline or pioglitazone administration in sham rats (C). Pioglitazone did not change paw withdraw latencies to noxious heat. n = 8–10 per group.