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. 1975 Aug;72(8):3129–3133. doi: 10.1073/pnas.72.8.3129

Chromosomal localization of human genes governing the interferon-induced antiviral state.

C Chany, M Vignal, P Couillin, N Van Cong, J Boué, A Boué
PMCID: PMC432934  PMID: 1059098

Abstract

Interferon sensitivity of different normal and aneusomic human cells and of different mouse-human hybrids cells has been compared. G21 trisomic cells are more sensitive than diploid cells; whereas, on the contrary, triploid cells are normal in their human interferon sensitivity. Among other aneusomic cell lines tested, E16 trisomic cells are significantly less sensitive. These data are in favor of the hypotheses that the G21 chromosome carries genetic information for structural proteins involved in the receptor system for interferon, that there is a regulatory mechanism governing the antiviral state, and that the E16 chromosome is a possible candidate for carrying information for such a depressive regulatory mechanism. None of the chromosome abnormalities studies are involved with interferon synthesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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