Table 2.
Summary of Ub+ inclusions and pneumocyte injury among interstitial pneumonias and other lung diseases
| DAD | UIP | NSIP | OP | AEF | CLE | |
|---|---|---|---|---|---|---|
| Light microscope | ||||||
| Inclusions (no. of cases) | 22/54 | 26/35 | 5/28 | 2/34 | 1/9 | 0/5 |
| Mean numbers of inclusions/slide | 27 | 11.8 | 2.3 | 1.5 | 0.1 | 0 |
| Immunostaining | ||||||
| Ub+ inclusions (no. of cases) | 26 | 28 | 11 | 5 | 2 | 0 |
| Mean numbers of Ub+ cells/slide | 67.4 | 34.4 | 10.9 | 4.6 | 0.3 | 0 |
| Scores* for: | ||||||
| Erosion | 1.8 | 1.6 | 1.1 | 0.9 | 0.01 | 0 |
| Intraluminal granulation tissue | 2.8 | 2.7 | 2.1 | 1.2 | 0.8 | 0 |
| Interstitial fibrosis | 2.0 | 2.8 | 2.2 | 1.1 | 1.0 | 0.1 |
DAD: diffuse alveolar damage; UIP: usual interstitial pneumonia; NSIP: non-specific interstitial pneumonia; OP: organizing pneumonia; AEF, airspace enlargement with fibrosis; CLE: centrilobular emphysema.
*
Scores 0–3 according to the severity or extent of the lesion.