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. 1975 Aug;72(8):3163–3166. doi: 10.1073/pnas.72.8.3163

Chemotactic signals induce cell differentiation in Dictyostelium discoideum.

M Darmon, P Brachet, L H Da Silva
PMCID: PMC432941  PMID: 171655

Abstract

Experiments carried out with the aid of cellophane membranes demonstrate that the morphogenetic block of certain nonaggregating, "aggregateless," mutants may be overcome by diffusible factors excreted by aggregating wild-type cells. The same differentiation process into aggregation-competent cell is observed if mutant amoebae are subjected to external 3':5'-cAMP pulses imposed at 5 min intervals. Wild-type amoebae also respond to cAMP pulses, since the onset of differentiation is more precocious in pulsed than in unpulsed populations. These data suggest that chemotactic signals act as an inducer of cell differentiation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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