Abstract
Anti-idiotypic antibodies were prepared in (CBA X C57BL/6)F1 hybrid mice by immunization either with CBA anti-C57BL/6 alloantiserum or with purified CBA thymus-processed lymphoid cells (T cells) Iodinated anti-mouse Ig or triple sandwich ferritin-labeling techniques served to visualize the reaction between idiotype and anti-idiotype. From 5 to 10% of purified CBA T cells appeared to carry receptors for C57BL/6 antigens. Heavily labeled cells had the morphology of small lymphocytes.
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- Aguet M., Bächi T. Comparison of the direct and indirect immunoferritin tagging of Sendai virus antigen. Ann Immunol (Paris) 1973 Aug;124(3):407–416. [PubMed] [Google Scholar]
- Binz H., Lindenmann J. Cellular receptors: binding of radioactively labeled anti-alloantiserum. J Exp Med. 1972 Oct 1;136(4):872–884. doi: 10.1084/jem.136.4.872. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Binz H., Lindenmann J., Wigzell H. Cell-bound receptors for alloantigens on normal lymphocytes. I. Characterization of receptor-carrying cells by the use of antibodies to alloantibodies. J Exp Med. 1974 Apr 1;139(4):877–887. doi: 10.1084/jem.139.4.877. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Binz H., Lindenmann J., Wigzell H. Cell-bound receptors for alloantigens on normal lymphocytes. II. Antialloantibody serum contains specific factors reacting with relevant immunocompetent T lymphocytes. J Exp Med. 1974 Sep 1;140(3):731–741. doi: 10.1084/jem.140.3.731. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Binz H., Lindenmann J., Wigzell H. Inhibition of local graft-versus-host reaction by anti-alloantibodies. Nature. 1973 Nov 16;246(5429):146–148. doi: 10.1038/246146a0. [DOI] [PubMed] [Google Scholar]
- Bordenave G. L'idiotypie comparée des anticorps de lapins différents contre Salmonella abortus-equi et contre le virus de la mosaïque du tabac. Observation d'une réactivité croisée entre certains idiotypes d'anticorps contre ces deux matériels antigéniques. Eur J Immunol. 1973 Nov;3(11):726–731. doi: 10.1002/eji.1830031114. [DOI] [PubMed] [Google Scholar]
- CARO L. G., VAN TUBERGEN R. P., KOLB J. A. High-resolution autoradiography. I. Methods. J Cell Biol. 1962 Nov;15:173–188. doi: 10.1083/jcb.15.2.173. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Crone M., Koch C., Simonsen M. The elusive T cell receptor. Transplant Rev. 1972;10:36–56. doi: 10.1111/j.1600-065x.1972.tb01538.x. [DOI] [PubMed] [Google Scholar]
- Ford W. L., Atkins R. C. The proportion of lymphocytes capable of recognizing strong transplantation antigens in vivo. Adv Exp Med Biol. 1973;29(0):255–262. doi: 10.1007/978-1-4615-9017-0_37. [DOI] [PubMed] [Google Scholar]
- Golstein H. P., Svedmyr E. A., Jondahl M., Wigzell H. Impact of fractionation procedures on lymphocyte activities in vitro and in vivo. Separation of cells with high concentrations of surface immunoglobin. Transplant Proc. 1972 Sep;4(3):311–319. [PubMed] [Google Scholar]
- Howard J. C., Wilson D. B. Specific positive selection of lymphocytes reactive to strong histocompatibility antigens. J Exp Med. 1974 Sep 1;140(3):660–672. doi: 10.1084/jem.140.3.660. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Matter A., Lisowska-Bernstein B., Ryser J. E., Lamelin J. P., Vassalli P. Mouse thymus-independent and thymus-derived lymphoid cells. II. Ultrastructural studies. J Exp Med. 1972 Nov 1;136(5):1008–1030. doi: 10.1084/jem.136.5.1008. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nisbet N. W., Simonsen M., Zaleski M. The frequency of antigen-sensitive cells in tissue transplantation. A commentary on clonal selection. J Exp Med. 1969 Mar 1;129(3):459–467. doi: 10.1084/jem.129.3.459. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Oudin J., Michel M. Idiotypy of rabbit antibodies. I. Comparison of idiotypy of antibodies against Salmonella typhi with that of antibodies against other bacteria in the same rabbits, or of antibodies against Salmonella typhi in various rabbits. J Exp Med. 1969 Sep 1;130(3):595–617. doi: 10.1084/jem.130.3.595. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Perkins W. D., Karnovsky M. J., Unanue E. R. An ultrastructural study of lymphocytes with surface-bound immunoglobulin. J Exp Med. 1972 Feb 1;135(2):267–276. doi: 10.1084/jem.135.2.267. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ramseier H., Lindenmann J. Aliotypic antibodies. Transplant Rev. 1972;10:57–96. doi: 10.1111/j.1600-065x.1972.tb01539.x. [DOI] [PubMed] [Google Scholar]
- Ramseier H., Lindenmann J. Cellular receptors. effect of anti-alloantiserum on the recognition of transplantation antigens. J Exp Med. 1971 Nov 1;134(5):1083–1094. doi: 10.1084/jem.134.5.1083. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ramseier H., Lindenmann J. Similarity of cellular recognition structures for histocompatibility antigens and of combining sites of corresponding alloantibodies. Eur J Immunol. 1972 Apr;2(2):109–114. doi: 10.1002/eji.1830020203. [DOI] [PubMed] [Google Scholar]
- Wells J. V., Fudenberg H. H., Givol D. Localization of idiotypic antigenic determinants in the Fv region of murine myeloma protein MOPC-315. Proc Natl Acad Sci U S A. 1973 May;70(5):1585–1587. doi: 10.1073/pnas.70.5.1585. [DOI] [PMC free article] [PubMed] [Google Scholar]