Skip to main content
PMC home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1975 Sep;72(9):3300–3304. doi: 10.1073/pnas.72.9.3300

Transcription termination and late control in phage lambda.

J W Roberts
PMCID: PMC432979  PMID: 1059112

Abstract

A transcription termination site occurs between the promoter for late gene expression of bacteriophage lambda and the late genes themselves. It is proposed that the lambda Q gene product controls late gene expression by over-coming this termination barrier.

Full text

PDF

Images in this article

3301Image
on p.3301
3303Image
on p.3303

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adhya S., Gottesman M., De Crombrugghe B. Release of polarity in Escherichia coli by gene N of phage lambda: termination and antitermination of transcription. Proc Natl Acad Sci U S A. 1974 Jun;71(6):2534–2538. doi: 10.1073/pnas.71.6.2534. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bertrand K., Korn L., Lee F., Platt T., Squires C. L., Squires C., Yanofsky C. New features of the regulation of the tryptophan operon. Science. 1975 Jul 4;189(4196):22–26. doi: 10.1126/science.1094538. [DOI] [PubMed] [Google Scholar]
  3. Blattner F. R., Dahlberg J. E. RNA synthesis startpoints in bacteriophage lambda: are the promoter and operator transcribed? Nat New Biol. 1972 Jun 21;237(77):227–232. doi: 10.1038/newbio237227a0. [DOI] [PubMed] [Google Scholar]
  4. Court D., Sato K. Studies of novel transducing variants of lambda: dispensability of genes N and Q. Virology. 1969 Oct;39(2):348–352. doi: 10.1016/0042-6822(69)90060-9. [DOI] [PubMed] [Google Scholar]
  5. Franklin N. C. Altered reading of genetic signals fused to the N operon of bacteriophage lambda: genetic evidence for modification of polymerase by the protein product of the N gene. J Mol Biol. 1974 Oct 15;89(1):33–48. doi: 10.1016/0022-2836(74)90161-2. [DOI] [PubMed] [Google Scholar]
  6. Friedman D. I., Wilgus G. S., Mural R. J. Gene N regulator function of phage lambda immun21: evidence that a site of N action differs from a site of N recognition. J Mol Biol. 1973 Dec 25;81(4):505–516. doi: 10.1016/0022-2836(73)90519-6. [DOI] [PubMed] [Google Scholar]
  7. Herskowitz I. Control of gene expression in bacteriophage lambda. Annu Rev Genet. 1973;7:289–324. doi: 10.1146/annurev.ge.07.120173.001445. [DOI] [PubMed] [Google Scholar]
  8. Herskowitz I., Signer E. R. A site essential for expression of all late genes in bacteriophage lambda. J Mol Biol. 1970 Feb 14;47(3):545–556. doi: 10.1016/0022-2836(70)90321-9. [DOI] [PubMed] [Google Scholar]
  9. Lebowitz P., Weissman S. M., Radding C. M. Nucleotide sequence of a ribonucleic acid transcribed in vitro from lambda phage deoxyribonucleic acid. J Biol Chem. 1971 Aug 25;246(16):5120–5139. [PubMed] [Google Scholar]
  10. Minkley E. G., Pribnow D. Transcription of the early region of bacteriophage T7: selective initiation with dinucleotides. J Mol Biol. 1973 Jun 25;77(2):255–277. doi: 10.1016/0022-2836(73)90335-5. [DOI] [PubMed] [Google Scholar]
  11. Peacock A. C., Dingman C. W. Molecular weight estimation and separation of ribonucleic acid by electrophoresis in agarose-acrylamide composite gels. Biochemistry. 1968 Feb;7(2):668–674. doi: 10.1021/bi00842a023. [DOI] [PubMed] [Google Scholar]
  12. Portier M. M., Marcaud L., Cohen A., Gros F. Mechanism of transcription in the N operon of bacteriophage lambda. Mol Gen Genet. 1972;117(1):72–81. doi: 10.1007/BF00268839. [DOI] [PubMed] [Google Scholar]
  13. Richardson J. P., Grimley C., Lowery C. Transcription termination factor rho activity is altered in Escherichia coli with suA gene mutations. Proc Natl Acad Sci U S A. 1975 May;72(5):1725–1728. doi: 10.1073/pnas.72.5.1725. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Roberts J. W. Promoter mutation in vitro. Nature. 1969 Aug 2;223(5205):480–482. doi: 10.1038/223480a0. [DOI] [PubMed] [Google Scholar]
  15. Roberts J. W. Termination factor for RNA synthesis. Nature. 1969 Dec 20;224(5225):1168–1174. doi: 10.1038/2241168a0. [DOI] [PubMed] [Google Scholar]
  16. Rosenberg M., Weissman S., deCrombrugghe B. Termination of transcription in bacteriophage lambda. Heterogeneous, 3'-terminal oligo-adenylate additions and the effects of rho factor. J Biol Chem. 1975 Jun 25;250(12):4755–4764. [PubMed] [Google Scholar]
  17. Schleif R., Greenblatt J., Davis R. W. Dual control of arabinose genes on transducing phage lambda-dara. J Mol Biol. 1971 Jul 14;59(1):127–150. doi: 10.1016/0022-2836(71)90417-7. [DOI] [PubMed] [Google Scholar]
  18. Schleif R. The specificity of lamboid phage late gene induction (lamboid phage late gene specificity). Virology. 1972 Nov;50(2):610–612. doi: 10.1016/0042-6822(72)90413-8. [DOI] [PubMed] [Google Scholar]
  19. Segawa T., Imamoto F. Diversity of regulation of genetic transcription. II. Specific relaxation of polarity in read-through transcription of the translocated trp operon in bacteriophage lambda trp. J Mol Biol. 1974 Aug 25;87(4):741–754. doi: 10.1016/0022-2836(74)90082-5. [DOI] [PubMed] [Google Scholar]
  20. Studier F. W. Analysis of bacteriophage T7 early RNAs and proteins on slab gels. J Mol Biol. 1973 Sep 15;79(2):237–248. doi: 10.1016/0022-2836(73)90003-x. [DOI] [PubMed] [Google Scholar]
  21. Szpirer J., Brachet P. Relations physiologiques entre les phages tempérés lambda et phi80. Mol Gen Genet. 1970;108(1):78–92. doi: 10.1007/BF00343187. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES