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. 1975 Sep;72(9):3333–3336. doi: 10.1073/pnas.72.9.3333

A model for compartmentation of de novo and salvage thymidine nucleotide pools in mammalian cells.

D Kuebbing, R Werner
PMCID: PMC432986  PMID: 1059118

Abstract

When [3H]thymidine is added to HeLa cells grown in thymidine-free medium it is incorporated into DNA almost immediately at full specific activity, blocking any further incorporation of de novo synthesized thymidine nucleotides. Apparently, de novo nucleotide pools [Baumunk, C.N. & Friedman, D.L. (1971) Cancer Res. 31, 1930--35] and salvage nucleotide pools are compartmentalized in HeLa cells. After one generation in the presence of thymidine, the cells begin utilizing nucleotides from both pools to about equal extent.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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